吴允昆

个人简介
科研项目
学术论文
获奖
专利
承担教学
研究生培养

姓名：吴允昆	性别：
民族：	年龄：
最高学历：	学位：
学习和工作经历　　1992.09 - 1996.06　武汉大学生命科学学院学士　　2002.12 - 2007.06 美国University of Alabama at Birmingham 博士　　2007.07 - 2007.12 美国University of Alabama at Birmingham 博士后　　2008.01 - 2011.06 美国HHMI/UT Southwestern 博士后/研究员　　2011.07 - 2017.06 中国科学院福建物质结构研究所研究员/课题组长、学位/学术委员会委员　　2017.07 - 福建师范大学生命科学学院/南方生物医学中心教授　　研究简介　　本研究组主要综合运用结构生物学手段解析重要功能蛋白的空间结构，通过高分辨率结构深入阐释蛋白机器的作用机制，进而理解其生物功能或病生机理，成果以第一作者在Nature和Nature Structural & Molecular Biology等、以通讯作者在Plant Cell等杂志上发表。　　在蛋白质结构与功能的基础上，结合计算生物和化学合成等手段，设计开发基于特定蛋白靶的分子调控性药物以及运载系统，以实现靶蛋白的应用及改造，主要致力于新型疫苗、抗体、多肽和小分子药物等及其功能运载体的研发，成果以通讯作者发表在Biomaterials等杂志。　　研究生获奖　　赵艳和 2011级博士，2016年荣获中国科学院福建物质结构研究所优秀毕业生一等奖　　吴秀玲 2012 级博士, 2013年荣获国家奖学金

　　代表性论文（* 通讯作者；# 共同第一作者）

　　1.Wu Y, Yang Y, Ye S, Jiang Y. (2010) Structure of the Intracellular Gating Ring from the Human High-conductance Ca2+-gated K+ Channel. Nature 466(7304):393-7.

　　2.Wu Y, Sha B. (2006). Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p. Nature Structural & Molecular Biology 13(7):589-93.

　　3.Li S, Zhao Y, Zhao Z, Wu X, Sun L, Liu Q, Wu Y*. (2016) Crystal structure of GRAS domain of SCARECROW-LIKE 7 in Oryza sativa. Plant Cell 2016 May;28(5):1025-34 DOI: 10.1105/tpc.16.00018 (highlighted article, 生物1区； IF 9.338)

　　4.Zhang L, Zeng Z, Hu C, Bellis SL, Yang W, Su Y, Zhang X, Wu Y*. (2016) Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines. Biomaterials 2016 Jan;77:307-19. doi: 10.1016/j.biomaterials.2015.11.009. (生物材料1区；IF：8.557)

　　5.Zhang L*, Fan Y, Wu Y*. (2014) Inositol based none-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines. Biomaterials 2014 Feb;35(6):2039-50. doi: 10.1016/j.biomaterials.2013.11.034. (生物材料1区；IF：8.557)

　　6.A luminescent layered hybrid Ag–Ru/LDH as a photocatalytic antibacterial agent. Fangnan Xiao, Xiaolin Liu, Yue Xiao, Fangman Chen，Yunkun Wu*. New Journal of Chemistry 2017 June 41 7260-7266

　　7.Sun L, Chen P, Su Y, Cai Z, Ruan L, Xu X, Wu Y*. Crystal structure of thermostable alkylsulfatase SdsAP fromPseudomonas sp. S9.Biosci Rep. 2017 May 11;37(3) doi: 10.1042/BSR20170001.

　　8.Crystal structure of the type IV secretion system component CagX from Helicobacter pylori.Zhang J, Fan F, Zhao Y, Sun L, Liu Y, Keegan RM, Isupov MN, Wu Y*.Acta Crystallogr F Struct Biol Commun. 2017 Mar 1;73(Pt 3):167-173. doi:10.1107/S205323017001376. Epub 2017 Feb 28.

　　9.Lifang Sun, Yintao Su, Yanhe Zhao, Zheng-qing Fu, Yunkun Wu*.（2016）Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus. Scientific Reports.2016 Aug 30;6:32309. doi: 10.1038/srep32309. (IF 5.228)

　　10.Zhang L, Hu C, Yang W, Liu X, Wu Y*. （2016）Chemical synthesis, versatile structures and functions of tailorable adjuvants for optimizing oral vaccination. ACS Appl Mater Interfaces. 2016 Dec 28;8(51):34933-34950. doi: 10.1021/acsami.6b10470 (工程技术一区；IF: 7.145)

　　11.Shengping Li, Yintao Su, Yadan Liu, Lifang Sun, Minxiang Yu, Yunkun Wu*. （2016）Preparation and characterization of cross-linked enzyme aggregates (CLEAs) of recombinant thermostable alkylsulfatase (SdsAP) from Pseudomonas sp. S9. Process Biochemistry51(12)：2084–2089. DOI：10.1016/j.procbio.2016.09.013

　　12.Lifang Sun, Yunkun Wu*. (2016) Envelope protein VP24 from White spot syndrome virus: expression, purification and crystallization.Acta Crystallogr F Struct Biol Commun. 2016 Aug;72(Pt 8):586-90. doi: 10.1107/S205323016009055.

　　13.Xianren Ye, Yanhe Zhao, Xiuling Wu, Yintao Su, Yunkun Wu*, Feifei She*. (2015) Identification of residues involved in nucleotidyltransferase activity of JHP933 from helicobacter pyloriby site-directed mutagenesis. Archives of Biological Sciences 01/2015; DOI:10.2298/ABS150622127Y

　　14.Su Y, Shi F, Zeng Z, Wu X, Zhao Y, Zhang L, Xie Z*, Wu Y*.(2015) A Versatile Monoclonal Antibody Specific Against Human DAB2IP.Monoclon Antib Immunodiagn Immunother. Aug;34(4):246-50. doi: 10.1089/mab.2015.0012.

　　15.Zhang L*, Bellis SL, Fan Y, Wu Y*. (2015) Using Inositol as a Biocompatible Ligand for Efficient Transgene expression.International Journal of Nanomedicine. 2015:10 2871-84. (工程技术一区；IF: 4.32)

　　16.Zhao Y, Ye X, Su Y, Sun L, She F*, Wu Y*. (2014) Crystal structure confirmation of JHP933 as a nucleotidyltransferase superfamily protein from Helicobacter pylori strain J99. PLoS One 2014 Aug 7;9(8):e104609. doi: 10.1371/journal.pone.0104609.

　　17.Zhang L*, Hu C, Fan Y, Wu Y*. (2013) Binary gene vectors based on hyperbranched poly(L-lactide-co-polyglycerol) and polyethylenimine for prolonged transgene expression via co-assembly with DNA into fiber core–shell triplexes. J. Mater. Chem. B1(45), 6271-6282 (工程技术一区；IF: 6.627)

　　18.Li J#, Wu Y*, Qian X, Sha B. (2006). Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex. Biochemical Journal398(3): 353-60.

　　19.Wu Y, McCombs D, Nagy L, Delucas L, Sha B. (2006). Preliminary X-ray crystallographic studies of yeast mitochondrial protein Tom70p. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62(Pt 3):265-7.

　　20.Wu Y, Li J, Jin Z, Fu Z, Sha B. (2005). The crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 reveals novel dimerization motif for Hsp40. Journal of Molecular Biology 346(4):1005-11.

　　21.Tao J, Wu Y, Ron D, Sha B. (2008). Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58 (IPK) TPR fragment.Acta Crystallogr Sect F Struct Biol Cryst Commun. 64(Pt 2):108-10.

　　22.Hu J, Wu Y, Li J, Qian X, Fu Z, Sha B. (2008) The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1. BMC Structural Biology 8:3.