曹小红

　　1.国家“十二五”科技支撑计划项目“增强免疫功能因子的制备关键技术及其应用”

　　2.国家863计划项目 “食品微生物基因组改造”

　　3.国家863计划项目“大宗食品发酵安全低碳加工关键技术研究”

　　4.国家农业科技成果转化资金项目“酱制品发酵生产关键技术研究与产业化”

　　5.天津市科技支撑计划重点项目“米曲霉功能基因组研究”

　　6.教育部“长江学者和创新团队发展计划”食品安全与营养关键控制技术研究

　　主持完成的主要科研项目

　　1.国家“十一五”科技支撑计划重点项目“传统发酵食品安全控制及产业化示范”

　　2.国家863计划项目“家蝇抗病毒肽的功能域分析及作用机制研究”

　　3.国家自然科学基金项目“家蝇凝集素的氨基酸序列分析及免疫活性研究”

　　4.天津市科技转化项目“高盐稀态酱油质量安全控制技术生产性试验”

　　5.天津市科技转化项目“利用现代高新技术改造传统的酱油生产技术”

　　6.江西省对外合作项目“健胃消食片矫味技术的研究”

　　1.Purification and antitumour activity of a lipopeptide biosurfactant produced by Bacillus natto TK‐1. Biotechnology and Applied Biochemistry. 2009, 52, 97-106.

　　2.evaluation of a lipopeptide biosurfactant from Bacillus natto TK-1 as a potential source of anti-adhesive, antimicrobial and antitumor activities. Brazilian Journal of Microbiology. 2009, 40, 373-379.

　　3.A D-galactose binding lectin with mitogenic activity from Musca domestica pupae. Zoological Science. 2009, 26, 249-253.

　　4.Surfactin Induces apoptosis and G(2)/M arrest in human breast cancer MCF-7 cells through cell cycle factor regulation. Cell Biochem. Biophys. 2009, 55, 163-171.

　　5.Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway. Chemico-Biological Interactions. 2010,183, 357-362.

　　6.Effect of overexpression of transcription factors on the fermentation properties of Saccharomyces cerevisiae industrial strains. Letters in Applied Microbiology. 2009, 49: 14-19.

　　7.Genome shuffling of Zygosaccharomyces rouxii to accelerate and enhance the flavour formation of soy sauce. Journal of the Science of Food and Agriculture. 2010, 90, 281-285.

　　8.Improvement of soy-sauce flavour by genome shuffling in Candida versatilis to improve salt stress resistance. International Journal of Food Science & Technology. 2010, 45, 17-22.

　　9.Purification and characterization of a new D-galactose specific lectin from the housefly, Musca domestica, and its antiproliferative effect on human K562 and MCF-7 tumor cells Journal of Insect Science. 2010, 79, 1-12.

　　10.A novel approach for the improvement of ethanol fermentation by Saccharomyces cerevisiae. Canadian Journal of Microbiology. 2010, 56, 495-500.

　　11.Effects of soybean isoflavone on the notch signal pathway of the brain in rats with cerebral ischemia. J Nutr Sci Vitaminol. 2009, 55, 326-331.

　　12.Effects of genistein on oxidative injury in endothelial cells. J Nutr Sci Vitaminol. 2008, 54, 402-408.

　　13.Genome Shuffling of Hansenula anomala to Improve Flavour Formation of Soy Sauce. World Journal of Microbiology and Biotechnology. 2012, 28, 1857-1862.

　　14.Musca domestica larva lectin induces apoptosis in bel-7402 cells through a mitochondria-mediated reactive oxygen species way. Biol. Pharm. Bull. 2010, 33(8), 1274-1278.

　　15.Preparation and anticoagulation activity of a chemically sulfated polysaccharide (S-GFB) obtained from Grifola frondosa, Journal of Food Biochemistry. 2010, 34, 1049-1060.

　　16.Purification and in vitro anti-tumor activity in MCF-7 cells of lectin from Musca domestica larvae. Journal of Insect Science. 2010, 10, 164.

　　17.Enhancing the concentration of 4-vinylguaiacol in top-fermented beers- a review.Journal of the American society of brewing chemists. 2010, 68, 77-82.

　　18.Gene cloning of phenolic acid decarboxylase from Bacillus subtilis and expression in top-fermenting yeast strains. African Journal of Biotechnology. 2010, 9, 5284-5291

　　19.CLP induces apoptosis in K562 cells through Ca2+ regulating ERK activation. Cancer letters. 2008, 276, 221-227.

　　20.Lectin purified from musca domestica pupae up-regulates NO and iNOS production via the activation of NF-KB in macrophages. International Immunopharmacology. 2011, 11, 399-405.

　　21.ROS-Ca2+ is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis. Chemico-Biological Interactions. 2011, 190(1), 16-27

　　22.Identification of salt-tolerant gene HOG1 in Torulopsis versatilis. Biotechnol Lett. 2011, 33(7), 1449-1456.

　　23.A lectin from Musca domestica pupae stimulates B cell proliferation and enhances IL-12 production via ERK1/2-NF-kappa B signaling pathways. Biotechnol Lett. 2011, 33(8), 1545-1550.

　　24.Musca domestica pupa lectin improves the immunomodulatory activity of macrophages by activating NF-kBk, Journal of medicinal food, 2012, 15, 145-151

　　25.Construction of the mutant strain in Aspergillus oryzae 3.042 for abundant proteinase production by the N+ ion implantation mutagenesis, International Journal of Food Science & Technology. 2012, 47, 501-510.

　　26.Musca domestica pupae lectin induces apoptosis in HepG2 cells through a NF-κB/p65-mediated caspase pathway. Bulletin du Cancer. 2012, 99(4), 49-54.

　　27.Comparative  proteome  analysis  of  Aspergillus  oryzae  3.042  and  A.  oryzae  100-8  strains: towards the production of different soy sauce flavors. Journal of Proteomics，2012, 75( 13), 3914-3924.

　　28.Genome shuffling to improve fermentation properties of acetic acid bacterium by the improvement of ethanol tolerance. International Journal of Food Science & Technology. 2012, 47(10), 2184-2189.

　　29.Draft genome sequence of Aspergillus oryzae Strain 3.042. Eukaryotic Cell. 2012,11(9), 1178

　　30.An antitumor peptide from Musca domestica pupae (MATP) induces apoptosis in HepG2 cells through a JNK-mediated and Akt-mediated NF-κB pathway. Anticancer Drugs. 2012, 23(8), 827-835.

　　31.Inhibition on Hepatitis B virus in vitro of lectin from Musca domestica pupa by activating NF-κB. Virus Research. 2012,170, 53-58.

　　32.Functional properties of soy sauce and metabolism genes of strains for fermentation. International Journal of Food Science and Technology 2012 doi:10.1111/j.1365-2621.2012.03219.x

　　33.Immunomodulation of polyunsaturated fatty acids purified from Nitzschia Laevis Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

　　34.Immunomodulation Activity of Lectin Isolated from Musca Domestica (Housefly) Pupae Bioinformatics and Biomedical Engineering, 2009. ICBBE 2009. 3rd International Conference on 11-13 2009 Page(s):1-6.

　　35.Effect of Adding Salt-Tolerant Microorganisms on the Flavor of Soy Sauce. International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings, p 7500-7502, 2011 DOI: 10.1109/RSETE.2011.5966106

　　36.Research on salt-tolerant gene HOG1 in Torulopsis versatilis, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings, p 8454-8456, 2011 DOI: 10.1109/RSETE.2011.5964131

　　37.Immunomodulatory effect of lectin from Musca domestic pupa on immunosuppressive mice. Proceedings 2011 International Conference on Human Health and Biomedical Engineering, HHBE 2011, p 11-14, DOI: 10.1109/HHBE.2011.6027885

　　38.Musca domestica larvae lectin induced apoptosis in human breast cancer MCF-7 cells through ROS-JNK mediated caspase pathway and ROS-Ca2+ pathway. 5th International Conference on Bioinformatics and Biomedical Engineering, ICBBE 2011, DOI:  10.1109/icbbe.2011.5780249

　　主编完成的著作

　　《食品安全与卫生》，科学出版社，2013年

　　《食品安全科学知识》，中国政法大学出版社，2012年

　　《食品安全与卫生学》，科学出版社，2006年

　　《食品营养学》，中国轻工出版社，2005年

　　招收研究生学科及方向

　　1.招收博士研究生

　　（1）生物技术与食品工程酿造过程中的工程菌代谢机理

　　（2）食品科学功能性食品及其保健机理

　　2.招收硕士研究生

　　（1）食品科学食品生物技术

　　（2）营养与食品卫生学食品安全分析技术

　　（3）食品工程营养与功能食品