近期负责和参加的主要科研项目

　　1. 教育部新世纪优秀人才支持计划（2012－2014）

　　2. 基于可控基因与环境扰动的毕赤酵母合成S-腺苷甲硫氨酸系统代谢工程研究(国家自然科学基金，2010－2012)

　　3. 纳米羟基磷灰石的抗肿瘤活性及其分子机理研究（上海市科委纳米专项，2009－2011）

　　4. 构建用于毕赤酵母表达系统的启动子文库（教育部留学归国人员基金，2008－2010）

　　5. 启动子文库及其在重组毕赤酵母合成S-腺苷甲硫氨酸代谢分析中的应用（上海市科委“浦江人才”计划，2007－2009）

　　6. 工业生物技术的过程科学基础研究（“973”项目，2007－2011）

　　7. 红霉素生产菌种的代谢工程改造、发酵过程优化及产业化研究（上海市科委重点项目，2007－2010）

　　代表性论著

　　1. Qian JC, Qin XL, Yin Q, Chu J, Wang YH. Cloning and characterization of Kluyveromyces marxianus Hog1 gene. Biotechnol. Lett. 2010, 33(3): 571-575.

　　2. Qian JC, Lavker RM, Tseng H. Mapping ribosomal RNA transcription activity in the mouse eye. Dev. Dynam. 2006, 235(7): 1984-1993.

　　3. Qian JC, Cai XP, Chu J, Zhuang YP, Zhang SL. Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains. Biotechnol. Lett. 2006, 28(12 ): 937-941.

　　4. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL, Chu J*. GAP promoter library for fine-tuning gene expression in Pichia pastoris. Appl. Environ. Microb., 2011, 77(11): 3600-3608.

　　5. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL, Chu J*. Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Lett. Appl. Microbiol. 2011, 52(6): 634-641.

　　6. Zhang QL, Wu JQ, Qian JC*, Chu J, Zhuang YP, Zhang SL, Liu W*. Knocking out of tailoring genes eryK and eryG in an industrial  erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C, and D at different conversion ratios. Lett. Appl. Microbiol. 2010, 52: 129-137.

　　7. Zhao QH, Qian JC*, Zhou HJ, Yuan Y, Mao YH, Liu CS*. In vitro osteoblast-like and endothelial cells response to calcium silicate/calcium phosphate cement. Biomed. Mater. 2010, 5(3): 035004.

　　8. Hu H, Qian JC*, Chu J*, Wang Y, Zhuang YP, Zhang SL. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. J. Biotechnol., 2009, 141(3-4): 97-103.

　　9. Hu H, Qian JC*, Chu J*, Wang YH, Zhuang YP, Zhang SL. Optimization of L-Methionine feeding strategies for improving S-adenosyl-Lmethionine production by methionine adenosyltransferase overexpressed Pichia pastoris. Appl. Microbiol. Biotechnol., 2009, 83(6): 1105-1114.

　　10. Lu X, Qian JC, Zhou HJ, Gan Q, Tang W, Lu JX, Yuan Y, Liu CS. In vitro cytotoxicity and apoptosis-induction of silica nanoparticles in human hepatoma HepG2 cells. Int. J. Nanomed., 2011, 6: 1889-1901.

　　11. Zhou HJ, Qian JC, Wang J, Yao WT, Liu CS, Chen JG and Cao XH. Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo. Biomaterials, 2009, 30 (9): 1715-1724.

　　12. Yuan Y, Liu CS, Qian JC, Wang J, Zhang Y. Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells. Biomaterials, 2010, 31 (4): 730-740.

　　13. Gan Q, Lu XY, Yuan Y, Qian JC, Zhou HJ, Lu X, Shi JL, Liu CS. A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles- capped mesoporous silica. Biomaterials, 2011, 32 (7): 1932-1942.

　　14. Zhang SL, Cao XJ, Chu J, Qian JC, Zhuang YP. Bioreactors and Bioseparation, Biotechnology in China: Chemicals, Energy & Envronment. Advances in Biochemical Engineering-Biotechnology, 2010, 122: 105-150.

　　15. Chen Y, Deng W, Wu JQ, Qian JC, Chu J, Zhuang YP, Zhang SL, Liu W. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. Appl. Environ. Microb., 2008, 74 (6): 1820-1828.

　　16. Zou X, Zeng W, Chen CF, Qi XC, Qian JC, Chu J, Zhuang YP, Zhang SL, Li WJ.  Fermentation optimization and industrialization of recombinant Saccharopolyspora erythraea strains for improved erythromycin A production.  Biotechnol. Bioproc. E, 2010, 15 (6): 959-968.

　　17. Chen HX, Chu J, Zhang SL, Zhuang YP, Qian JC, Wang YH, Hu XQ.  Intracellular expression of Vitreoscilla hemoglobin improves S-adenosylmethionine production in a recombinant Pichia pastoris.  Appl. Microbiol. Biotechnol., 2007, 74 (6): 1205-1212.

　　获奖

　　1. 2011年国家科技进步二等奖：基于细胞生理与过程信息处理的工业发酵优化新技术. （6）

　　2. 2008年上海市科技进步一等奖：先进技术集成的红霉素生产新工艺. （6）

　　申请专利

　　1. 钱江潮, 秦秀林, 于晓光, 储炬, 武晓乐, 庄英萍, 张嗣良. GAP启动子文库在调节S-腺苷甲硫氨酸代谢途径中的应用. 申请号: 201010621230.1, 申请日期: 2010-12-31.

　　2. 钱江潮, 秦秀林, 储炬, 庄英萍, 张嗣良, 肖慈英. GAP启动子文库及其用途. 申请号: 200910053198.9, 申请日期: 2009-6-17, 公开号 CN101922047A, 公开日期: 2010.12.22.

　　3. 刘昌胜, 林俊, 钱江潮, 袁媛. 优化的基于大肠杆菌表达系统的重组人骨形态发生蛋白-2的DNA序列及重组人骨形态发生蛋白-2的制备，申请号200910045832.4, 申请日期: 2009-1-23, 公开号 CN101787369A.

　　4. Liu CS, Lin J, Qian JC, Yuan Y. Optimized DNA sequences encoding recombinant human bone morphogenetic protein-2 (rhbmp-2), preparation method and the uses thereof, Application No. US 12/623527 filed on 23-Nov-2009. Publication No. US 2010/0190209 A1 published on 29-Jul-2010. US 7947821 B2, Date of Patent: 24-May-2011.

　　5. 庄英萍, 王晖, 储炬, 张嗣良, 钱江潮, 王永红. 重组的降糖肽及其生产菌株的构建和培养方法.申请号: 200710037133.6, 申请日期: 2007-2-5, 公开号CN101029081A.