现承担和参与的主要科研项目

　　1．人类重要生理功能基因的高通量筛选与开发研究（863）

　　2．肝癌发生发展的分子网络调控机制与干预位点研究 (卫生部重大专项项目)

 

　　代表论文

　　1. Zhong W, Shen WF, Ning BF, Hu PF, Lin Y, Yue HY, Yin C, Hou JL, Chen YX, Zhang JP, Zhang X, Xie WF. Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats. Hepatology. 2009 Jul 22;50(5):1524-1536. [Epub ahead of print]

　　2. Yue HY, Yin C, Hou JL, Zeng X, Chen YX, Zhong W, Hu PF, Deng X, Zhang JP, Ning BF, Shi J, Zhang X, Lin Y, Xie WF Hepatocyte nuclear factor 4{alpha} attenuates hepatic fibrosis in rats. Gut. 2009 Aug 10. [Epub ahead of print]

　　3. Zheng DL, Zhang L, Cheng N, Xu X, Deng Q, Teng XM, Wang KS, Zhang X, Huang J, Han ZG.. Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol. 2009 Feb;50(2):377-387

　　4. Chuan Yin, Yong Lin, Xin Zhang, Yue-Xiang Chen, Xin Zeng, Hai-Yan Yue, Jun-Liang Hou, Xing Deng, Jun-Ping Zhang, Ze-Guang Han, Wei-Fen Xie. Differentiation Therapy of Hepatocellular Carcinoma in Mice with Recombinant Adenovirus Carrying Hepatocyte Nuclear Factor-4" Gene. Hepatology. 2008 Nov;48(5):1528-39.

　　5. Xin Zhang, Dao-Hong Lin, Yan Jin, Ke-Sheng Wang, Yan Zhang, Elisa Babilonia, ZhiJian Wang, Zhiqin Wang，Gerhard Giebisch, Ze-Guang Han, and Wen-Hui Wang. Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9517-22.

　　6. Jian Huang, Xin Zhang, Min Zhang, Jing-De Zhu, Yun-Li Zhang, Yun Lin, Xiao-fei Qi, Qin Zhang, Guang-Zhen Liu, Jian Yu, Ying Cui, Zhi-Qin Wang, Ze-Guang Han. Upregulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis, 2007 May;28(5):1094-103 （共同第一作者）

　　7. Zhang X, Wang KS, Wang ZQ, Xu LS, Wang QW, Chen F, Wei DZ, Han ZG. Nuclear localization signal of ING4 plays a key role in its binding to p53. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1032-8.

　　8. Zhang X, Xu LS, Wang ZQ, Wang KS, Li N, Cheng ZH, Huang SZ, Wei DZ, Han ZG. ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. FEBS Lett. 2004 Jul 16;570(1-3):7-12.

　　9. Qiang H, Lin Y, Zhang X, Zeng X, Shi J, Chen YX, Yang MF, Han ZG, Xie WF. Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis. Liver Int. 2006 Nov;26(9):1126-37.

　　10. Qi J, Zhang X, Zhang HK, Yang HM, Zhou YB, Han ZG ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor. Mol Cell Biochem. 2006 Oct;290(1-2):159-67

　　11. Xu ZG, Du JJ, Zhang X, Cheng ZH, Ma ZZ, Xiao HS, Yu L, Wang ZQ, Li YY, Huo KK, Han ZG. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Hepatology. 2003 38(3):735-44

　　12. Wei-Fen Xie, Xin Zhang,et al. Trans-activation of the mouse cartilage-derived retinoic acid-sensitive protein gene by Sox9. J Bone Miner Res. 1999;14:757-763

　　13. Wei-Fen Xie, Xin Zhang, Linda J. Sandell. The 2.2-kb promoter of cartilage- derived retinoic acid-sensitive protein controls gene expression in cartilage and embryonic mammary buds of transgenic mice. Matrix Biology, 2000；19:501-509

　　14. 路美玲， 陈斐，王勤婉，韩泽广，张新。生长抑制因子ING5 在肝癌中的表达分析。《胃肠病学》（已接受）

　　15. 李婷婷，程志红，王克生，陈斐，韩泽广，张新。胰岛素受体酪氨酸激酶底物基因的克隆表达及其对细胞形态的影响。《医学分子生物学杂志》 2009 6(3)

　　16. 黄丽钰，王克生，韩泽广，张新. 肝癌相关基因DLK1转基因小鼠的构建与鉴定. 《中华消化杂志》 2008/05

　　17. 潘春阳，王克生，王勤婉，韩泽广，张新.ING4核定位信号和PHD指状结构域共同调控MAPK通路中ERK1的激活。《 医学分子生物学杂志》 2008/02

　　获奖情况

　　1. 2007年度上海市自然科学奖二等奖

　　乙型肝炎病毒相关肝癌的功能基因组学研究 （第三完成人）

　　2. 2007年明治乳业生命科学奖 科学奖

　　3. 2005年上海市生物工程学会“生龙达学术交流奖”三等奖